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Clinical application of Aspen CEPROLAC™

Obligatory body loss of protein is a small fraction of total protein synthesized by the body under normal conditions. But losses become severe under conditions of critical illness with excessive protein losses occurring through:

  • Body fluids- gastric reflux, nasogastric regurgitations of gastric residuals or fistula losses.
  • Gastrointestinal (GI) tract, skin or lungs- These are organs with a large surface area of epithelial cells. Losses are greatest when disease/medical treatment implicates the small intestine.
  • Urinary loss- state of hyper metabolism with tissue breakdown, nephrosis and chronic kidney disease.

Protein requirements as a percentage of basal requirements are increased 30% by mild Illness, 60% by moderate illness and 100% by severe illness. Patients with needs for high Level of protein synthesis benefit from high-protein formulae if they experienced poor appetite and anorexia

In addition specific disease requirements may require the restriction of total protein because of accumulation of toxic metabolites such as ammonia [cirrhosis] or urea [chronic kidney disease] from the abnormal metabolic processing of aromatic and sulphur containing amino acids. When this occurs, the increased use of branched chain amino acids or BCAA (leucine, isoleucine and valine) is suggested to minimize the accumulation of the toxic metabolites.

The essential amino acid (EAAs) content also becomes critical when dietary protein is restricted in patients because the protein quality of the diet is affected where restriction is recommended.

Ceprolac is a unique proprietary protein blend of high quality cation exchange whey isolate boosted with hydrolyzed WPI, it is for people with increased protein demands and those who are not able to meet their protein needs with a normal diet.

Benefits associated with the use of Ceprolac, a unique blend of Cation Exchange WPI and Hydrolyzed WPI, are categorized in the Table below. Patients undergoing chemotherapy or under conditions of chronic disease associated with continuous depletion of lean body mass and/or poor oral intake are likely to benefit from the use of these products.

The gram-to-gram content of essential amino acids, branched chain amino acids and nitrogen content in one gram of Ceprolac protein consumed is a critical determinant of the quality. The product may also be favorable to patients with hospital malnutrition as these patients are likely to be mmunocompromised.

Glutamine which is non-essential becomes conditionally essential in hyper-catabolic Conditions, Glutamine is generated from the skeletal muscle under these conditions and used as a fuel by the intestine because of the high rate of villous atrophy, ulcerations and necrosis.

BENEFIT

WHY

CLINICAL RELEVANCE

Better absorption

  • Delivers protein peptides, not whole proteins which take longer to digest
  • Homogeneity of peptide size

 

 

  • Hepatic disease- impaired liver function may require withholding or limiting protein in the presence of elevated blood ammonia. The use of supplemental BCAA improves nitrogen balance and encephalopathy.
  • Radiation enteritis- radiation therapy for treatment of carcinomas/ obstructive tumours of the upper gastrointestinal (GI) system will also damage the mucosal lining (inflammation) thus affecting secretion, digestion and absorption functions
  • Feeding intolerance [following sepsis, trauma, burns]
  • Short bowel syndrome- surgical shortening of the bowel affects absorptive and excretory function and depends on the site and length of the resected bowel. Overall reduction in absorptive area
  • Inflammatory bowel disease such as Crohn’s disease and ulcerative colitis are recurrent and result in malabsorption of fat, fluids, nutrient and bile acids.  Protein-energy malnutrition arises from catabolism and deficiency particularly protein-losing enteropathy.
  • Pancreatic insufficiency- lack of protein digestive enzymes affects the breakdown of complete proteins and limits the availability of amino acids from these proteins.
  • Intestinal carcinoma- obstruction by tumours in the intestine limits digestion and absorption
  • Cystic fibrosis- affects exocrine and mucus-secreting glands causing pancreatic insufficiency and severe fat malabsorption. Results in poor digestion of complete protein as secretion of protein enzymes are limited.

 

Higher bioavailability

  • Nitrogen retention and utilization is higher
  • Complete and high EAAs profile
  • Intestinal fistulas
  • Feeding intolerance
  • Burns
  • HIV/AIDS
  • Hypoalbuminemia
  • Critical illness

 

Maintains GI integrity

  • Prevents bacterial translocation
  • Minimizes osmotic diarrhea as product is lactose-free
  • Chronic diarrhea
  • Radiation enteritis
  • Add on L Glutamine for enteral priming to maintain gut integrity

 

Improved outcome and tolerance

  • Enhances gastric emptying, thereby reducing aspiration by tube feeding
  • Fat malabsorption unlikely because fat content is minimal
  • Lactose intolerance unlikely as product is lactose-free (<0.8 g/100g)

  • Delayed gastric emptying
  • Elevated gastric residuals
  • Bariatric surgery (stomach reduction/ bypass)

 

Promotes tissue repair

  • Proteins are assimilated rapidly
  • Rapid peak in plasma amino acids
  • Increase in protein synthesis
  • BCAA promotes anabolism

 

Rapid wound healing as in:

  • Burns
  • Pressure sores
  • Large surgical incisions

Appropriate for diabetics, elderly and hemi- or quadriplegics

 

 


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Use only as directed. Always read the label. If symptoms persist, please consult your doctor.
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